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Laboratory of Molecular Architecture

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Areas of Interest

Design of Water-Soluble Variants of Membrane Proteins (the QTY Code)

Applying the QTY code to design water-soluble variants of GPCRs. — Applying the QTY code to design water-soluble variants of GPCRs.

Four water molecules surround the side chains of glutamine and asparagine, and three water molecules surround the side chains of serine, threonine, and tyrosine. — Four water molecules surround the side chains of glutamine and asparagine, and three water molecules surround the side chains of serine, threonine, and tyrosine.

Water-soluble QTY-variant GPCRs retain form and ligand binding activity in water. — Water-soluble QTY-variant GPCRs retain form and ligand binding activity in water.

Structural comparison of designed water-soluble GPCRs and native GPCRs, superimposed, distinguished by color. — Structural comparison of designed water-soluble GPCRs and native GPCRs, superimposed, distinguished by color.

Molecular Design of Self-Assembling Peptide Materials

First discovery of self-assembling peptides in yeast. — First discovery of self-assembling peptides in yeast.

From peptides to hydrogels. — From peptides to hydrogels.

From peptide scaffold hydrogel to sustained protein release. — From peptide scaffold hydrogel to sustained protein release.

First report of lipid-like peptide nanotubes. — First report of lipid-like peptide nanotubes.

Designed surface self-assembling peptides. — Designed surface self-assembling peptides.

From single peptides to peptide nanofibers to a peptide scaffold. — From single peptides to peptide nanofibers to a peptide scaffold.

Pathway to a self-assembling single nanofiber. — Pathway to a self-assembling single nanofiber.

Design of lipid-like peptides. — Design of lipid-like peptides.

Lipid-like peptide nanotubes. — Lipid-like peptide nanotubes.

Lipid-like peptide nanotubes. — Lipid-like peptide nanotubes.

3-D Cell Biology & Regenerative Medicine

Neural stem cells in self-assembling peptide nanofiber scaffold. — Neural stem cells in self-assembling peptide nanofiber scaffold.

Neurons forming synapses in peptide scaffold hydrogel. — Neurons forming synapses in peptide scaffold hydrogel.

Details of cells embedded in 3-D self-assembling peptide scaffold. — Details of cells embedded in 3-D self-assembling peptide scaffold.

Human cells producing Type I and Type III collagen in peptide hydrogel scaffold. — Human cells producing Type I and Type III collagen in peptide hydrogel scaffold.

Cell migration in three dimensions. — Cell migration in three dimensions.

Single peptide to scaffold used for neurons, stem cells, cartilage, bone, and brain tissue repair. — Single peptide to scaffold used for neurons, stem cells, cartilage, bone, and brain tissue repair.

Biosolar Energy Nanodevices and Biosolar Hydrogen Production

Biosolar cells. — Biosolar cells.