Self-Assembling Peptide Scaffolds

  1. Shuguang Zhang, Todd Holmes, Curtis Lockshin, Alexander Rich. Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc. Natl. Acad. Sci. USA, 1993, 90, pp.  3334-3338. [local pdf]

  2. Shuguang Zhang, Curtis Lockshin, Richard Cook, Alexander Rich. Unusually stable β-sheet formation in an ionic self-complementary oligopeptide. Biopolymers, 1994, 34, 663-672. [local pdf]

  3. Shuguang Zhang, Todd C. Holmes, C. Michael DiPersio, Richard O. Hynes, Xing Su, Alexander Rich. Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials, 1995, 16, 1385-1393. [local pdf]

  4. Shuguang Zhang, Alexander Rich. Direct conversion of an oligopeptide from a β-sheet to an α-helix: A model for amyloid formation. Proc. Natl. Acad. Sci. USA, 1997, 94, pp. 23–28. [local pdf]

  5. Erasmo J. Leon, Neeta Verma, Shuguang Zhang, Douglas A. Lauffenburger, Roger D. Kamm. Mechanical properties of a self-assembling oligopeptide matrix. Journal of Biomaterials Science, Polymer Edition, 1998, 9, 297-312. [local pdf]

  6. Shuguang Zhang, Michael Altman. Peptide self-assembly in functional polymer science and engineering. Reactive & Functional Polymers, 1999, 41, 91–102. [local pdf]

  7. Todd C. Holmes, Sonsoles de Lacalle, Xing Su, Guosong Liu, Alexander Rich, and Shuguang Zhang. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc. Natl. Acad. Sci. USA, 2000, 97 (12), 6728–6733. [publisher link] [local pdf]

  8. Michael Altman, Peter Lee, Alexander Rich, and Shuguang Zhang. Conformational behavior of ionic self-complementary peptides. Protein Science, 2000, 9:1095–1105. [local pdf]

  9. Michael R. Caplan, Peter N. Moore, Shuguang Zhang, Roger D. Kamm, Douglas A. Lauffenburger. Self-assembly of a β-sheet potein foverned by relief of electrostatic repulsion relative to van der Waals attraction. Biomacromolecules, 2000, 1, 627-631. [local pdf]

  10. Michael R. Caplan, Elissa M. Schwartzfarb, Shuguang Zhang, Roger D. Kamm, Douglas A. Lauffenburger. Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence. Biomaterials, 2002, 23, 219–227. [local pdf]

  11. Michael R. Caplan, Elissa M. Schwartzfarb, Shuguang Zhang, Roger D. Kamm, Douglas A. Lauffenburger.  Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial.  J. Biomaterials Science Polymer Edition, 2002, 13, 225-236.

  12. J. Kisiday, M. Jin, B. Kurz, H. Hung, C. Semino, S. Zhang, A. J. Grodzinsky. Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: Implications for cartilage tissue repair. Proc. Natl. Acad. Sci. USA, 2002,  99  (15), 9996–10001. [local pdf]

  13. Davide M. Marini, Wonmuk Hwang, Douglas A. Lauffenburger, Shuguang Zhang, Roger D. Kamm. Left-Handed Helical Ribbon Intermediates in the Self-Assembly of a β-Sheet Peptide. Nano Letters, 2002, 2 (4), 295-299. [local pdf]

  14. Shuguang Zhang.  (2003) Fabrication of novel materials through molecular self-assembly. Nature Biotechnology 21, 1171-1178. [publisher link] [local pdf]

  15. Wonmuk Hwang, Davide M. Marini, Roger D. Kamm, Shuguang Zhang. Supramolecular structure of helical ribbons self-assembled from a β-sheet peptide. Journal of Chemical Physics, 2003, 118 (1), 389-397. [local pdf]

  16. Yooseong Hong, Raymond L. Legge, S. Zhang, P. Chen. Effect of amino acid sequence and pH on nanofiber formation of self-assembling peptides EAK16-II and EAK16-IV. Biomacromolecules, 2003, 4, 1433-1442. [local pdf]

  17. Carlos E. Semino, Joshua R. Merok, Gracy G. Crane, Georgia Panagiotakos, Shuguang Zhang. Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds. Differentiation, 2003, 71, 262–270. [local pdf]

  18. Wonmuk Hwang, Shuguang Zhang, Roger D. Kamm, Martin Karplus. Kinetic control of dimer structure formation in amyloid fibrillogenesis. Proc. Natl. Acad. Sci. USA, 2004, 101 (35), 12916–12921. [local pdf]

  19. Carlos E. Semino, Jiro Kasahara, Yasunori Hayashi, Shuguang Zhang. Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold. Tissue Engineering, 2004, 10 (3/4), 643-655. [local pdf]

  20. Maria A. Bokhari, Galip Akay, Shuguang Zhang, Mark A. Birch. The enhancement of osteoblast growth and differentiation in vitro on a peptide hydrogel—polyHIPE polymer hybrid material. Biomaterials, 2005, 26, 5198–5208. [local pdf]

  21. Michael E. Davis, J.P. Michael Motion, Daria A. Narmoneva, Tomosaburo Takahashi, Daihiko Hakuno, Roger D. Kamm, Shuguang Zhang, Richard T. Lee. Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation, 2005 111, 442-450. [local pdf]

  22. Elsa Genove, Colette Shen, Shuguang Zhang, Carlos E. Semino. The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function. Biomaterials, 2005, 26, 3341–3351. [local pdf]

  23. Daria A. Narmoneva, Olumuyiwa Oni, Alisha L. Sieminski, Shugang Zhang, Jonathan P. Gertler, Roger D. Kamm, Richard T. Lee. Self-assembling short oligopeptides and the promotion of angiogenesis. Biomaterials, 2005, 26, 4837–4846. [local pdf]

  24. Hidenori Yokoi, Takatoshi Kinoshita, Shuguang Zhang. Dynamic reassembly of peptide RADA16 nanofiber scaffold. Proc. Natl. Acad. Sci. USA, 2005, 102 (24), 8414–8419. [local pdf]

  25. Michael E. Davis, Patrick C. H. Hsieh, Tomosaburo Takahashi, Qing Song, Shuguang Zhang, Roger D. Kamm, Alan J. Grodzinsky, Piero Anversa, Richard T. Lee. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc. Natl. Acad. Sci. USA, 2006, 103 (21), 8155–8160. [local pdf]

  26. Rutledge G. Ellis-Behnke, Yu-Xiang Liang, David K.C. Tay, Phillis W.F. Kau, Gerald E. Schneider, Shuguang Zhang, Wutian Wu, Kwok-Fai So. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine: Nanotechnology, Biology, and Medicine, 2006, 2, 207– 215. [local pdf]

  27. Rutledge G. Ellis-Behnke, Yu-Xiang Liang, Si-Wei You, David K. C. Tay, Shuguang Zhang, Kwok-Fai So, Gerald E. Schneider. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc. Natl. Acad. Sci. USA, 2006, 103 (13), 5054–5059. [local pdf]

  28. Fabrizio Gelain, Daniele Bottai, Angleo Vescovi, Shuguang Zhang. Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS ONE, 2006, Issue 1, e119. [local pdf]

  29. Yusuke Nagai, Larry D. Unsworth, Sotirios Koutsopoulos, Shuguang Zhang. Slow release of molecules in self-assembling peptide nanofiber scaffold. Journal of Controlled Release, 2006, 115, 18–25. [local pdf]

  30. Fabrizio Gelain, Akihiro Horii, Shuguang Zhang. Designer self-assembling peptide scaffolds for 3-D tissue cell cultures and regenerative medicine. Macromol. Biosci., 2007, 7, 544–551. [local pdf]

  31. Fabrizio Gelain, Andrea Lomander, Angelo L. Vescovi, Shuguang Zhang. Systematic studies of self-assembling peptide nanofiber scaffold with other scaffolds. Journal of Nanoscience and Nanotechnology, 2007, Vol. 7, 1–11. [local pdf]

  32. Akihiro Horii, Xiumei Wang, Fabrizio Gelain, Shuguang Zhang. Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration. PLoS ONE, 2007, Issue 2, e190. [local pdf]

  33. Ying Chau, Ying Luo, Alex C.Y. Cheung, Yusuke Nagai, Shuguang Zhang, James B. Kobler, Steven M. Zeitels, Robert Langer. Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides e A model for biofunctional scaffolds. Biomaterials, 2008, 29, 1713–1719. [local pdf]

  34. Zhongli Luo, Xiaojun Zhao, Shuguang Zhang. Self-organization of a chiral D-EAK16 designer peptide into a 3D nanofiber scaffold. Macromol. Biosci. 2008, 8, 785-791. [local pdf]

  35.  Zhongli Luo, Xiaojun Zhao, Shuguang Zhang. Structural dynamic of a self-assembling peptide d-EAK16 made of only d-amino acids. PLoS ONE, 2008, 3 (5), e2364. [local pdf]

  36. Xiumei Wang, Akihiro Horii, Shuguang Zhang. Designer functionalized self-assembling peptide nanofiber scaffolds for growth, migration, and tubulogenesis of human umbilical vein endothelial cells. Soft Matter, 2008, 4, 2388–2395. [local pdf]

  37. Sotirios Koutsopoulosa, Larry D. Unsworth, Yusuke Nagai, Shuguang Zhang. Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold. Proc. Natl. Acad. Sci. USA, 2009, 106 (12), 4623-4628. [local pdf]

  38. Fabrizio Gelain, Larry D. Unsworth, Shuguang Zhang. Slow and sustained release of active cytokines from self-assembling peptide scaffolds. Journal of Controlled Release, 2010, 145, 231–239. [local pdf]

  39.  Yoshiyuki Kumada, Shuguang Zhang. Significant Type I and Type III Collagen Production from Human Periodontal Ligament Fibroblasts in 3D Peptide Scaffolds without Extra Growth Factors. PLoS ONE, 2010, 5 (4), e10305. [local pdf]

  40. Yoshiyuki Kumada, Nathan A. Hammond, Shuguang Zhang. Functionalized scaffolds of shorter self-assembling peptides containing MMP-2 cleavable motif promote fibroblast proliferation and significantly accelerate 3-D cell migration independent of scaffold stiffness. Soft Matter, 2010, 6, 5073-5079. [local pdf]

  41. Zhongli Luo, Shunkang Wang, Shuguang Zhang. Fabrication of self-assembling D-form peptide nanofiber scaffold d-EAK16 for rapid hemostasis. Biomaterials, 2011, 32, 2013–2020. [local pdf]

  42. Sotirios Koutsopoulos, Shuguang Zhang. Long-term three-dimensional neural tissue cultures in functionalized self-assembling peptide hydrogels, Matrigel and Collagen I. Acta Biomaterialia, 2012, 5162-5169. [local pdf]

  43. Sotirios Koutsopoulos, Shuguang Zhang. Two-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies. Journal of Controlled Release, 2012, 160, 451-458. [local pdf]

  44. Xi Liu, Xiumei Wang, Akihiro Horii, Xiujuan Wang, Lin Qiao, Shuguang Zhang, Fu-Zhai Cui. In vivo studies on angiogenic activity of two designer self-assembling peptide scaffold hydrogels in the chicken embryo chorioallantoic membrane. Nanoscale, 2012, 4, 2720–2727. [local pdf]

  45. Bryan B. Hsu, William Conway, Cory M. Tschabrunn, Manav Mehta, Monica B. Perez-Cuevas, Shuguang Zhang, Paula T. Hammond. Clotting mimicry from robust hemostatic bandages based on self-assembling peptides. ACS Nano, 2015, 9, 9394-9406. [local pdf]

  46. Gelain F., Zongli Luo, and Zhang, S. (2020) Self-assembling peptide EAK16 and RADA16 nanofiber hydrogel scaffolds. Chemical Reviews 120 (24) 13434–13460. [local pdf]

  47. Fabrizio Gelain, Zhongli Luo, Marc Rioult and Shuguang Zhang. Self-assembling peptide scaffolds in the clinic. npj Regenerative Medicine (2021) 6:9; https://doi.org/10.1038/s41536-020-00116-w. [local pdf]